Localized Dysbiosis of lactobacilli and the Clostridium leptum Subgroup May Be Related to UC

This study (related to my previous post) highlights how there is localized dysbiosis (i.e. bacterial imbalances) in ulcerative colitis patients. Specifically, the lactobacilli and Clostridium leptum subgroups are lower than expected.

Also, the concentration of these bacteria were actually different within the same patient from site to site within their colon.

Here's the excerpt:

The data revealed that lactobacilli and the Clostridium leptum subgroup were significantly different between the ulcerated and the nonulcerated regions. It also was noted that for lactobacilli, the composition varied significantly between biopsy sites irrespective of the location of UC in the gut but that the composition of the Clostridium leptum subgroup showed significant differences between paired samples from UC in the rectum and not in the left colon. Localized dysbiosis of the mucosa-associated intestinal microflora, especially for lactobacilli and the Clostridium leptum subgroup, may be closely related to UC.